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KMID : 0606920060140040194
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Biomolecules & Therapeutics
2006 Volume.14 No. 4 p.194 ~ p.201
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General Pharmacological Study of GCSB-5, a Herbal Formulation
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Park Sang-Won
Lee Chan-Ho
Kim Sung-Hwa
Cho Young-Jae
Heo Jeong-Haing
Park Jin-Gu
Cheon Ho-Jun
Lee Sung-Youl
Kim Jie-Wan
Lee Sun-Mee
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Abstract
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The general pharmacological properties of GCSB-5, a herbal formulation consisting of 6 Oriental herbs (Ledebouriellae Radix, Achyranthis Radix, Acanthopanacis Cortex, Cibotii Rhizoma. Glycine, Semen and Eucommiae Cortex), were investigated in mice, rats, guinea pigs and rabbits. The administration of GCSB-5 had no effect on general behavior and did not influence the central nervous system. Mean blood pressure, heart and respiratory rate and contractile response of the isolated guinea pig atrium were unaffected by the treatment of GCSB-5. Addition of GCSB-5 did not cause spontaneous relaxation and contraction of the isolated guinea pig ileum and rat uterus. And also, GCSB-5 had no effect on the gastrointestinal system and the blood system of the animals examined in this study. GCSB-5, and higher dosed (1,000 and 3,000 mg/kg), increased the urinary excretion of electrolytes, however, the urinc volume and pH in rats were unaffected. Taken together, these results indicate that GCSB-5 dose not induce any adverse effects in experimental animals and is expected to have no significant general harmacological activities.
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KEYWORD
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GCSB-5, General pharmacology
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